CGRP Blockers

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CGRP(Calcitonin gene-related peptide)-blocking drugs have been in development for several years. CGRP is released during a migraine. [1] The triptan class of drug may at least partially inhibit the release of CGRP. [1]

Multiple drug companies are developing an anti-CGRP drug, and have advanced to Phase III testing. [2] The drugs are currently being developed as both acute and preventative treatments.[3]


  1. 1.0 1.1 L Edvinsson. "CGRP blockers in migraine therapy: where do they act?" Macmillan Publishers Limited; British Journal of Pharmacology (2008) 155, 967–969
  2. Carroll, John. "UPDATED: Alder rockets up as promising migraine data heats up a frenzied race for CGRP drug approval." FierceBiotech, March 28, 2016. September 17, 2016.
  3. Smyres, Kerrie. TheraSpecs Blog, June 23, 2016. "New Migraine Drugs that Target CGRP Show Promise in Recent Studies" September 17, 2016.