CGRP(Calcitonin gene-related peptide)-blocking drugs have been in development for several years. CGRP is released during a migraine.  The triptan class of drug may at least partially inhibit the release of CGRP. 
- L Edvinsson. "CGRP blockers in migraine therapy: where do they act?" Macmillan Publishers Limited; British Journal of Pharmacology (2008) 155, 967–969
- Carroll, John. "UPDATED: Alder rockets up as promising migraine data heats up a frenzied race for CGRP drug approval." FierceBiotech, March 28, 2016. http://www.fiercebiotech.com/r-d/updated-alder-rockets-up-as-promising-migraine-data-heats-up-a-frenzied-race-for-cgrp-drug September 17, 2016.
- Smyres, Kerrie. TheraSpecs Blog, June 23, 2016. "New Migraine Drugs that Target CGRP Show Promise in Recent Studies" https://www.theraspecs.com/blog/new-migraine-drugs-that-target-cgrp-show-promise-in-recent-studies/ September 17, 2016.