CGRP Blockers

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CGRP(Calcitonin gene-related peptide)-blocking drugs have been in development for several years. CGRP is released during a migraine. [1] The triptan class of drug may at least partially inhibit the release of CGRP. [1]

Multiple drug companies are developing an anti-CGRP drug, and have advanced to Phase III testing. [2] The drugs are currently being developed as both acute and preventative treatments.[3]

References

  1. 1.0 1.1 L Edvinsson. "CGRP blockers in migraine therapy: where do they act?" Macmillan Publishers Limited; British Journal of Pharmacology (2008) 155, 967–969
  2. Carroll, John. "UPDATED: Alder rockets up as promising migraine data heats up a frenzied race for CGRP drug approval." FierceBiotech, March 28, 2016. http://www.fiercebiotech.com/r-d/updated-alder-rockets-up-as-promising-migraine-data-heats-up-a-frenzied-race-for-cgrp-drug September 17, 2016.
  3. Smyres, Kerrie. TheraSpecs Blog, June 23, 2016. "New Migraine Drugs that Target CGRP Show Promise in Recent Studies" https://www.theraspecs.com/blog/new-migraine-drugs-that-target-cgrp-show-promise-in-recent-studies/ September 17, 2016.