Magnesium sulfate

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Magnesium sulfate is a compound containing magnesium, sulfur and oxygen, with the formula MgSO4. It is a possible abortive treatment for migraines.

Not to be confused with the preventative treatment magnesium, which is typically administered orally, not intravenously.

Documented Dosage

1g intravenously over 15 minutes.[1]

Possible Side Effects

  • A brief flushed feeling / facial flusing[1][2]
  • Hypotension[2]
  • Lightheadedness[2]
  • Diarrhea[2]


One small study involved the abortive treatment of a migraine by administering 1g of magnesium sulfate over 15 minutes. 100% of the patients showed improvement, in either pain, or other symptoms. 87% of patients ultimately experienced lessening of pain. However, 86.6% also reported mild side effects to the treatment. [3]


  1. 1.0 1.1 Mauskop A, Altura BT, Cracco RQ, Altura BM."Intravenous magnesium sulfate rapidly alleviates headaches of various types." Headache. 1996 Mar;36(3):154-60. February 23, 2017.
  2. 2.0 2.1 2.2 2.3 Schnakenberg, Ellen. "Migraine Treatment: IV Magnesium Sulfate." May 15, 2013. February 23, 2017
  3. "Efficacy of intravenous magnesium sulfate in the treatment of acute migraine attacks." Gülhane Military Medical Academy Neurology Department, Ankara, Turkey. 2001. February 23, 2017