Migraine generator

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The "migraine generator" theory was developed by Professor H. C. Diener, of Essen, Germany.[1] He developed this theory based on a group of nerves in the brainstem which appeared to "turn on" at the beginning of the migraine, remain active for the duration of the migraine, and then "turn off" at the end of the migraine.[1] This area of the brain, likely the dorsal raphe nucleus, is referred to as the "migraine generator."[1]


  1. 1.0 1.1 1.2 Stewart J. Tepper, M.D. "Understanding Migraines and Other Headaches" UP of Mississippi, 2004, p. 26.